We investigate the mechanics of DNA based motor proteins, DNA binding proteins, and their substrates during fundamental processes. The action of molecular motors on DNA is inherently mechanical in nature. How they navigate DNA, how they collide and recover with DNA binding proteins, and how they restructure and reconfigure DNA topology all involve the generation of forces and torques that are critical for their function. We develop real‐time, often one of a kind, techniques that allow us to mechanically control, alter, and measure DNA topology and combine these with in vivo studies and computer simulations and modeling to decipher the mechanical properties and complex actions of biological molecules.

DNA Topology and Molecular Mechanics of Fundamental Processes

Technology Development

Our lab has a long history of pioneering technologies that mimic DNA‐based biological processes and our innovations are a major driving force for novel discoveries.